Generation of Rejuvenated Antigen-Specific T Cells by Reprogramming to Pluripotency and Redifferentiation
نویسندگان
چکیده
منابع مشابه
Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation.
Adoptive immunotherapy with functional T cells is potentially an effective therapeutic strategy for combating many types of cancer and viral infection. However, exhaustion of antigen-specific T cells represents a major challenge to this type of approach. In an effort to overcome this problem, we reprogrammed clonally expanded antigen-specific CD8(+) T cells from an HIV-1-infected patient to plu...
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ژورنال
عنوان ژورنال: Cell Stem Cell
سال: 2013
ISSN: 1934-5909
DOI: 10.1016/j.stem.2012.11.002